These are harder to get used to than the Thorne adrenal cortex.
I was out of whack for the first week and a half, my cortisol rasing at night and couldn't sleep. Then I started taking it earlier in the morning and I was able to go to sleep earlier and stay asleep and hour longer than usual.
I'll finish the bottle and see if it keeps improving. I got them because they had more bovine adrenal than the Thorne ones. But it just goes to show more isn't always better.
You have to find the right dose for you.